Mary&May Spicule Retinol PDRN Cream is a cream containing natural marine micro-spicules that are 1/40 the size of pores, nano-liposome retinol and the soothing ingredient panthenol. The formula helps improve wrinkles, pores and skin texture, while CICA PDRN soothes the skin and promotes recovery. 15 g

It contains 2,000 ppm of marine natural microscopic spicules (80–300 μm) that are smaller than pores and work intensively to improve wrinkles, pores and skin texture.
(15 g contains approximately 180,000–200,000 spicules.)

Contains 1,000 ppm of micro-sized nano-liposome retinol, which reduces skin irritation and improves both stability and absorption.

The formula also contains CICA PDRN, which targets damaged skin cells to promote skin recovery and regeneration, strengthen the collagen barrier, and soothe the skin while supporting the skin's healing process.

With 2% panthenol (vitamin B5), Ceramide NP, hyaluronic acid and allantoin, the Safe 4X formula is gentle enough even for sensitive skin.

Skin irritation test carried out.

Clinically proven effect

Triple improvement of pores (depth, area, density)
• Pore depth: 115.79%
• Pore area: 121.61%
• Pore density: 117.19%

Wrinkle reduction
• Wrinkles around the eyes: 112.24%
• Laugh lines: 110.20%

Improvement in skin texture: 114.42%
Improved skin firmness: 103.75%